Sampson holds a fine arts degree from the University of Maryland. He combines the skillful use of acrylic paints and vigorous broad brush strokes to create a canvas pulsating with rhythm and movement. A recurring theme in Sampson's work is the dominant male figure, done in epic and heroic scale. Sampson has been featured in numerous national publications recently, such as Town & Country, Playbill, American Visions, and Black Enterprise magazines. He has been critically recognized in the Washington Post for his first retrospective at the University of Maryland in 1997, and in the International Review of African American Art comprehensive guide for collecting in 1998.

In 1997, he was commissioned by Absolut Vodka to create ​a painting for their award winning ad campaign. Absolut. Sampson has been a part of a traveling collection which has made stops in Miami, New York, Detroit, Atlanta, Chicago, Houston, Philadelphia, and Washington, DC.